AICAR 100mg Pen

950.00 AED — In stock

AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) is a research compound studied for its role in cellular energy regulation, metabolic adaptation, and exercise physiology. It activates AMP-activated protein kinase (AMPK), a key regulator of energy balance, making it valuable for human-relevant studies on metabolism, endurance, and mitochondrial function. Key Features 🧪 cGMP manufactured in an FDA-registered facility ✅ ≥98% purity confirmed by HPLC analysis 📄 Batch-specific Certificates of Analysis (COAs) included 💉 Sterile, lyophilized pens for research use only Human-Relevant Research Applications 🏃 Exercise and endurance research — AICAR enhances metabolic pathways that mimic exercise‑induced AMPK activation, linked to increased endurance in preclinical models. PubMed: https://pubmed.ncbi.nlm.nih.gov/38873554/ 🧬 Mitochondrial energy studies — AICAR activates AMPK, the key regulator of cellular energy homeostasis, supporting efficient energy production and metabolic signaling. PubMed:https://pubmed.ncbi.nlm.nih.gov/34064363/ 💪 Muscle adaptation — AMPK activation by AICAR can protect muscle from inflammation‑driven atrophy and support metabolic resilience during energetic stress. PubMed: https://pubmed.ncbi.nlm.nih.gov/29844217/ Mechanism Summary Activates AMPK, a master energy sensor Promotes fatty acid oxidation and glucose uptake Enhances mitochondrial biogenesis and energy efficiency Frequently Research Questions How does AICAR improve endurance research models?By activating AMPK, AICAR increases cellular energy production and fatty acid oxidation, enhancing exercise capacity. What is the most relevant metabolic application?Human-relevant studies focus on glucose regulation, mitochondrial function, and energy adaptation. Does AICAR influence mitochondrial biogenesis?Yes. AMPK activation stimulates mitochondrial growth and ATP production efficiency. Scientific References McConell et al. (2010) – “AICAR increases mitochondrial biogenesis in L6 myotubes via AMPK” supports AMPK‑mediated mitochondrial effects of AICAR. PubMed: https://pubmed.ncbi.nlm.nih.gov/20044477/ Legal & Research Disclaimer This material is supplied exclusively for laboratory research use. It is not intended for diagnostic, therapeutic, cosmetic, human, or veterinary applications. The purchaser assumes all responsibility for compliance with applicable local, state, and federal regulations governing research compounds.

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What is AICAR 100mg Pen?

AICAR is a nucleoside analogue, not a peptide. Its full name is 5-aminoimidazole-4-carboxamide ribonucleoside, and it is also known as acadesine. It occurs naturally as an intermediate in the body's production of purines.

Inside cells, AICAR is converted to ZMP, which mimics AMP. This activates AMP-activated protein kinase (AMPK), an enzyme that acts as a cellular energy sensor. AMPK is involved in glucose uptake and fat use in muscle, which is why AICAR is widely used as a research tool.

Also known as: Acadesine, AICA riboside, 5-aminoimidazole-4-carboxamide ribonucleoside, Z-riboside

What are peptides?

What the research covers

AICAR has been studied extensively in cells and animals. A well-known 2008 mouse study reported that AICAR improved running endurance in sedentary mice, leading to the term 'exercise mimetic'. It has also been studied for effects on glucose uptake and insulin sensitivity. As acadesine, it was tested in human trials for heart protection during surgery and in some blood cancers, but it was not approved for those uses. AICAR is not approved as a medicine by the US FDA. It is also on the World Anti-Doping Agency prohibited list.

References

Narkar VA, Downes M, Yu RT. AMPK and PPARdelta agonists are exercise mimetics. Cell. 2008.

Formats available

Pen

Pre-filled pen prepared by a licensed compounding pharmacy for subcutaneous use.

Vial (injectable)

Vial for subcutaneous injection, prepared by a licensed compounding pharmacy.

Storage and handling

Storage: Keep pens refrigerated at 2-8C and protect them from light. Lyophilised vials should be refrigerated at 2-8C after reconstitution, kept away from light and never frozen. Follow the storage instructions on your pharmacy label.

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Specification

Property	Value
Type	Nucleoside analogue (AMPK activator), not a peptide
Molecular formula	C9H14N4O5
Molecular weight	approx. 258 g/mol
Formats	Pen, Vial (injectable)

Frequently asked questions

Is AICAR a peptide?

No. AICAR is a nucleoside analogue that activates the energy-sensing enzyme AMPK. It is listed alongside peptides because it is prescribed and supplied in the same way.

What does the research show?

Most research is in cells and animals, where it has been studied for endurance, glucose uptake and fat use. Human trials of acadesine looked at other uses and did not lead to approval.

Is AICAR allowed in sport?

No. AICAR is on the World Anti-Doping Agency prohibited list. Athletes subject to testing should not use it.

How should I store it?

Keep pens in the fridge, and refrigerate vials after reconstitution, away from light and never frozen. Follow the storage instructions on your pharmacy label.

Are there side effects?

Side effects can occur. Your GP will review your health, medication and, where relevant, blood results before prescribing, and you should report anything unexpected.