FOX-04 - Forkhead Box Protein

950.00 AED — In stock

Forkhead Box Protein 4‑D‑Retro‑Inverso (FOX‑04 / FOXO4‑DRI) is a synthetic senolytic peptide engineered to help selectively neutralize and remove senescent cells — aged or damaged cells that persist in tissues, contribute to chronic inflammation, impair recovery, and accelerate aging. By targeting the interaction between FOXO4 and p53, FOX‑04 facilitates programmed apoptosis of senescent cells, supporting tissue renewal, improved cellular environments, and research into longevity and anti‑aging pathways. Key Features 🧪 cGMP manufactured in an FDA‑registered facility✅ ≥98% purity confirmed by HPLC analysis📄 Batch‑specific Certificates of Analysis (COAs) included💉 Sterile, lyophilized vials for research use only Human‑Relevant Research Applications ⚡ Selective senescent cell apoptosis (senolysis)FOX‑04 peptide disrupts the FOXO4–p53 interaction, triggering p53‑mediated apoptosis selectively in senescent cells — a key mechanism underlying cellular senescence research.🔗 https://pubmed.ncbi.nlm.nih.gov/28340339/ 🧬 Targeting cellular aging pathwaysDesigned FOXO4‑based peptides have been shown to act as senolytic agents in human cell cultures by releasing p53 from senescent cell nuclei, enabling the removal of dysfunctional cells.🔗 https://pubmed.ncbi.nlm.nih.gov/40739602/ 📊 Reduced senescence markers in human modelsFOXO4‑derived peptides like FOXO4‑DRI have demonstrated the ability to reduce senescent cell burden in human chondrocytes and other cell models, providing a translational research tool for studying aging and tissue quality.🔗 https://pubmed.ncbi.nlm.nih.gov/33996787/ Mechanism Summary Disrupts FOXO4–p53 binding: Releases p53 from senescent cell nuclei, enabling apoptosis of aged/damaged cells. Selective senolytic action: Targets cells with high FOXO4 expression while sparing normal proliferating cells. Supports tissue homeostasis research: Clearing senescent cells can improve cellular environments for regeneration and reduce pro‑inflammatory signaling in experimental models. Reconstitution & Handling Guidance 1️⃣ Use sterile bacteriostatic water (0.9% benzyl alcohol)2️⃣ Add 3 ml of bacteriostatic water to reconstitute the peptide3️⃣ Gently swirl until fully dissolved (do not vortex)4️⃣ Store reconstituted peptide at 4 °C–10 °C for 2–3 months5️⃣ Unreconstituted peptide can be stored at 4 °C–10 °C until the expiration date Legal & Research Disclaimer This material is supplied exclusively for laboratory research use. It is not intended for diagnostic, therapeutic, cosmetic, human, or veterinary applications. The purchaser assumes all responsibility for compliance with applicable local, state, and federal regulations governing research compounds.

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What is FOX-04 - Forkhead Box Protein?

FOXO4-DRI is a synthetic peptide of 46 amino acids. It was designed by Peter de Keizer's research group and described in 2017. It is a D-retro-inverso peptide, meaning it is built from D-amino acids in reverse order. This design makes it more resistant to breakdown in the body.

In senescent cells, which have stopped dividing but do not die, the protein FOXO4 binds p53 and helps keep these cells alive. FOXO4-DRI is designed to interfere with this binding. In laboratory studies this allowed p53 to trigger cell death in senescent cells. Compounds that target senescent cells are called senolytics.

Also known as: FOXO4-DRI, FOXO4 D-retro-inverso peptide, Proxofim

What are peptides?

What the research covers

FOXO4-DRI is at a preclinical stage. The original 2017 study reported that it removed senescent cells in mice and was associated with improvements in fur, fitness and kidney function in aged and fast-ageing mice. Later cell and animal studies have explored its use in other tissues, and structural research has examined how it binds p53. There are no published controlled clinical trials of FOXO4-DRI in humans. Its safety and effects in people are unknown. FOXO4-DRI is not approved as a medicine by the US FDA or other major regulators.

References

Bourgeois B, Spreitzer E, Platero-Rochart D, et al.. The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI. Nature Communications. 2025.

Formats available

Vial (injectable)

Vial for subcutaneous injection, prepared by the pharmacy, prescription only.

Storage and handling

Storage: Vials are usually supplied lyophilised (freeze-dried). Once reconstituted, keep the vial refrigerated at 2-8°C, protected from light, and do not freeze. Follow the storage instructions on your pharmacy label.

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Specification

Property	Value
Structure	D-retro-inverso peptide (all D-amino acids, reversed sequence)
Peptide length	46 amino acids
Formats	Vial (injectable)

Frequently asked questions

What is a senolytic?

A senolytic is a compound designed to selectively remove senescent cells, which have stopped dividing but remain active. FOXO4-DRI has been studied as a senolytic in cell and animal research only.

What does the research on FOXO4-DRI show?

Studies in mice and cells suggest it can remove senescent cells. There are no published controlled human trials, so its effects and safety in people are not known.

How should I store FOX-04?

FOX-04 is supplied as a vial. Once reconstituted, keep it refrigerated at 2-8°C, protected from light, and do not freeze. Follow the storage instructions on your pharmacy label.

Are there side effects?

Side effects can occur. Your GP will review your health, medication and, where relevant, blood results before prescribing, and you should report anything unexpected. Because there is no published human trial data, side effects in people are not well described.